PUBLICATIONS

Note: *, co-corresponding; #, co-first author.

Full list of publications:
199

An operational perturbation proteomics-based virtual cell model

Rui Sun#, Liujia Qian#, Yongge Li#, Tong Liu#, Honghan Cheng, Xuedong Zhang, Xueya Zhou, Yuecheng Zhan, Guangmei Zhang, Zhengchao Lou, Kunpeng Ma, Chunlong Wu, Dongchen Ji, Zhangzhi Xue, Hongxue Meng, Yuhang Xiang, Dingwei Lei, Qianhe Zhou, Wenbin Hu, Yuhan Deng Lingling Tan, Qi Xiao, Zhiwei Liu, Lei Zeng, Liqin Qian, Xuan Zheng, Qiong Hu, Nianzi Luo, Weinan E, Peijie Zhou*, Han Wen*, Yi Zhu*, Tiannan Guo*.

Nature. 2026. accepted in principle

198

Toward the construction of a virtual yeast

Liujia Qian, Zizhuo Zhou, Peijie Zhou, Zhen Dong, Xudong Zhang, Zhenwu Dai, Zhangyang Gao, Siqi Sun, Kevin R. Roy, Shuaiyao Wang, Nicola Zamboni, Charles Boone, Michael Costanzo, Jianzhe Li, Gianni Liti, Jia-Xing Yue, Markus Ralser, Evan Williams, Mattia Zampieri, Heng Jiang, Tailin Wu, Yalin Wang, Feiran Li, Joseph Schacherer, Rui Sun, Zhaoxing Li, Yaming Deng, Yi Chen, Zhiping Xie, Huiqiang Lou, Xiaowen Wang, Linhai Xie, Han Wen, Liangyi Chen, Kai Lei, George Rosenberger, Xue Cai, Yingrui Wang, Qi Xiao, Huaizong Shen, Gaowen Liu, Lei Ma, Brenda Andrews, Hui Lu, Kiryl Piatkevich, Yi Zhu, Lei Bai, Yizhi Cai, Yuping Chen, Weinan E, Ge Gao, Fuchu He, Luonan Chen, Stan Z. Li, Hongwu Ma, Liang Qiao, Lars M. Steinmetz, Leihan Tang, Tang Tang, Xiaofan Zhang, Jing Yang, Yifan Yang, Kaicheng Yu, Jianyang Zeng, Yefeng Zheng, Bowen Zhou, Tiannan Guo*.

Nature. 2026. in press

197

Spatial distribution of the proteome in the human body and in cancers

Liang Yue#, Wenhao Jiang#, Sainan Li#, Meng Luo#, Ning Fan, Xiaolu Zhan, Rui Sun, Honghan Cheng, Zhangzhi Xue, Tong Liu, Qianhe Zhou, Kexin Chen, Tian Lu, Fang Guo, Dongwei Li,Weigang Ge, Zongxiang Nie, Mengge Lyu, Jun A, Yingrui Wang, Yingdan Chen, Zhenhai Fu, Nan Xiang, Lu Li, Fengchao Yu, Guo Ci Teo, Alexey I Nesvizhskii, Meng Wang, Michael P. Snyder, Ben C. Collins, Qi Xiao, Ruedi Aebersold, Fei Xu, Hui Yang, Sijia Zhang, Yi Han, Yi Zhu*, Yong Ji*, Yan Li*, Tiannan Guo*.

Nature. 2026 June 17.

196

MassNet: billion-scale AI-friendly mass spectral corpus enables robust de novo peptide sequencing

A Jun#, Xiang Zhang#, Xiaofan Zhang#, Jiaqi Wei#, Te Zhang, Yamin Deng, Pu Liu, Zongxiang Nie, Yi Chen, Nanqing Dong, Zhiqiang Gao*, Siqi Sun*, Tiannan Guo*.

Nature Methods. 2026. accepted in principle.

195

Minute-scale proteomics profiling resolves the chronological mechanics of yeast cell death

Zizhuo Zhou, Rui Sun, Zhaoxing Li, Shuaiyao Wang, Liujia Qian,Zhenwu Dai, Lei Zeng, Kunpeng Ma, Guangmei Zhang, Tiannan Guo*.

LangTaoSha Preprint Server, 2026 May. 29. DOI: https://doi.org/10.65215/LTSpreprints.2026.05.28.000257

194

DDA-BERT: end-to-end training for data-dependent acquisition mass spectrometry-based proteomics

Jun A#, Pu Liu#, Yingying Sun#, Jiaying Lin, Xiaofan Zhang, Zongxiang Nie, Yuqi Zhang, Ziyuan Xing, Yi Chen*, Tiannan Guo*.

Nature Communications. 27 April 2026.

193

Deeper is not always better in plasma proteomics

Huanhuan Gao, Kathrin Korff, Matthias Mann*, Tiannan Guo*.

Nature Biotechnology. 22 April 2026.

192

Blood proteomics: insights from public data

Asier Larrea-Sebal, Chengxin Dai, Alejandro J. Brenes, Kathrin Korff, Benjamin A. Neely, Philipp E. Geyer, Laura F. Dagley, Richard D. Unwin, Alexandra Naba, Michael J. MacCoss, Tiannan Guo, Eric W. Deutsch, Cesar Martin, Jochen M. Schwenk*, Yasset Perez-Riverol*.

Genome Biology. 2026 Mar 12;27(1):81. doi: 10.1186/s13059-026-04027-9. PMID: 41821120; PMCID: PMC12980870.

191

Large-scale metaproteomics of human gut microbiota reveals microbial functions in metabolic diseases and aging

Shuang Liang#, Yingying Sun#, Zelei Miao#, Bang-yan Li#, Ziyuan Xing, Yuting Xie , Enci Cai, Sainan Li, Pu Liu, Min Yang, Menglei Shuai, Wanglong Gou, Wenhao Jiang, Youming Wang, Huanhuan Gao, Ke Zhang, Jing Yu, Xue Cai, Xingbing Wang, Yi Zhu*, Yu-ming Chen*, Ju-Sheng Zheng*, Tiannan Guo*.

Cell Metabolism. 2026 Mar 13:S1550-4131(26)00055-Cell Metabolism0. doi: 10.1016/j.cmet.2026.02.012. Epub ahead of print. PMID: 41831436.

190

A targeted proteomics assay for the preoperative diagnosis of thyroid nodules

Xue Cai#, Yaoting Sun#, Dingcun Luo#, Hao Zhang#, Wenjun Wei#, Yifeng Zhang#, Weigang Ge#,Jing Liu, Guan Ruan, Lu Li, Lingling Tan, Luang Xu, Dong Xu, Haixia Guan, Jiang Zhu, Wanyuan Chen, Qiushi Zhang, Huijuan Si, Juntao Qiu, Zhangzhi Xue, Zhiqiang Gui, Haitao Zheng, Gaosong Wu, Jianhua Wang, Lei Xie, Guang Chen, Guoyang Wu, Lei Liang, Chuang Chen, Xianghui He, Meiping Shen, Jianbiao Wang, Minghua Ge, Deguang Zhang, Liang Zhou, Yijun Wu, Hui Shi, Fan Wu, Zhihong Wang, Hong Han, Jing Yao, Zhiyan Liu, Mingzhao Xing, Kennichi Kakudo, Yibo Gao, Wen Tian*, Huixiong Xu*, Yi Zhu*, Yu Wang*, Tiannan Guo*, We-TEC Investigators.

Cell Reports Medicine. 2026 Mar 10:102664. doi: 10.1016/j.xcrm.2026.102664. Epub ahead of print. PMID: 41812663.

189

Multimodal AI-enabled mass spectrometry-based expansion proteomics for whole-slide at single-cell resolution

Shuaiyao Wang#, Zhen Dong#*, Chunlong Wu, Jiayi Chen, Changao Li, Jianpeng Sheng, Xiang Li, Yi Chen*, Tiannan Guo*.

LangTaoSha Preprint Server. 2026 Feb. 20. DOI: 10.65215/LTSpreprints.2026.02.20.000134.

188

ProteoAutoNet: high-throughput co-eluted protein analysis with robotics and machine learning

Mengge Lyu, Pingping Hu, Guangmei Zhang, Kunpeng Ma, Xuedong Zhang, Pu Liu, Sai Zhang, Xiangqing Li, Rui Sun*, Yi Chen*, Tiannan Guo*.

Nature Communications. 2026 Jan 22;17(1):1949. doi: 10.1038/s41467-026-68686-9. PMID: 41571643; PMCID: PMC12929803.

187

Multi-center multi-omics integration predicts individualized prognosis in medullary thyroid carcinoma

Yan Zhou#, Yingrui Wang#, Xiao Shi#, Jiatong Wang#, Zelin Zang#, Likun Zhang#, Zhiqiang Gu, Xue Cai, Pingping Hu, Jiaxi Wang, Hanqing Liu, Zhihong Wang, Haixia Guan, Xiaohong Wu, Cenkai Shen, Yi He, Mo Li, Hao Zhang, Jianbiao Wang , Yijun Wu, Chuang Chen , Yi Zhu, Yaoting Sun*, Zhiyan Liu*, Yu Wang*, Tiannan Guo*.

Nature Communications. 2026 Jan 14;17(1):432. doi: 10.1038/s41467-025-67533-7. PMID: 41535264; PMCID: PMC12804720.

186

SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting

Zhang Y#, Silvestre-Roig C#, Fu H#, Alimohamadi H#, Mandal T, Chen JW, Luo EW, Anda J, Linard Matos AL, Richter M, Mennella A, Lee H, Chan LC, Wang Y, Wang N, Wang H, Wang X, Lee CK, Ghosh S, Matsui T, Weiss TM, Guo T, Zhang M, Li D, Wolfgang MC, Hagan RS, Li MMH, Gunzer M, Sickmann A, Frasca L, Yeaman MR, Lande R, Cui Q, Soehnlein O, Wong GCL*.

Proceedings of the National Academy of Sciences of the United States of America. 2026 Jan 13;123(2):e2521841122. doi: 10.1073/pnas.2521841122. Epub 2026 Jan 8. PMID: 41505524.

185

Systematic evaluation of blood contamination in nanoparticle-based plasma proteomics

Huanhuan Gao#, Yuecheng Zhan#, Yuanqi Liu#, Zhiyi Zhu, Yuxiu Zheng, Liqin Qian, Zhangzhi Xue, Honghan Cheng, Zongxiang Nie, Weigang Ge, Senlin Ruan, Jiaxu Liu, Jikai Zhang, Yingying Sun, Lei Zhou, Dongyue Xun, Yingrui Wang, Heyun Xu*, Huiwen Miao*, Yi Zhu*, Tiannan Guo*.

EMBO Molecular Medicine. 2026 Jan;18(1):275-296. doi: 10.1038/s44321-025-00346-9. Epub 2025 Dec 5. PMID: 41350775; PMCID: PMC12808129.

184

The suprachiasmatic nucleus regulates brown fat thermogenesis in male mice through an adrenergic receptor ADRB3-S100B signaling pathway

Yizhun Zeng, Xiaopeng Song, Qi Chen, Yue Gu, Jie Zhang, Tao Zhou, Zhihao Li, Tao Wang, Le Chang, Hongwei Yao, Yan Wang, Liyan Miao, Liujia Qian, Tiannan Guo, Yong Zhang, Sonia Rodriguez-Fernandez, Antonio Vidal-Puig*, Ying Xu*.

Plos Biology. 2025 Dec 4;23(12):e3003534. doi: 10.1371/journal.pbio.3003534. Epub ahead of print. PMID: 41343575.

183

Expansion omics: from expansion microscopy to spatial omics

Zhen Dong#*, Weirong Xiang#, Wenhao Jiang, Tiannan Guo*.

Molecular Systems Biology. 2026 Feb;22(2):165-178. doi: 10.1038/s44320-025-00171-9. Epub 2025 Dec 1. PMID: 41326779; PMCID: PMC12864849.

182

Rational tuning of temperature sensitivity of the TRPM8 channel

Lizhen Xu#, Xiao Liang#, Yunfei Wang#, Han Wen#, Wenxuan Zhen, Zhangzhi Xue, Fangfei Zhang, Xiao Yi, Xiaoying Chen, Lidan Hu, Bei Li, Bing Zhang, Zhenfeng Deng ,Wei Yang, Shilong Yang*, Tiannan Guo*, Yi Zhu* & Fan Yang*.

EMBO reports. 2025 Nov 14. doi: 10.1038/s44319-025-00630-2. Epub ahead of print. PMID: 41238795.

181

Cross-ethnic Molecular Signatures Underpin the Adverse Impact of Statin Use on Type 2 Diabetes

Fengzhe Xu#, Min Yang#, Wei Hu#, Shuai Yuan, Xue Cai, Wanglong Gou, Zelei Miao, Bang-yan Li, Liang Yue, Zhangzhi Xue, Menglei Shuai, Luqi Shen, Yuanqing Fu, Tiannan Guo*, Yu-ming Chen*, Ju-Sheng Zheng*

Genomics, Proteomics & Bioinformatics, 2025;, qzaf101, https://doi.org/10.1093/gpbjnl/qzaf101

180

Protein restriction reprograms the multi-organ proteomic landscape of mouse aging

Tian Lu#, Yuting Xie#, Yingrui Wang, Xiling Lin, Xue Cai, Yuqi Zhang, Zongxiang Nie, Chang Su, Wanglong Gou, Hong Zhang, Jing Wang, Yan Zhong, Zeyin Lai, Jingjing Xiang, Peng-Fei Shan, Ju-Sheng Zheng, Huijun Wang, Yi Zhu*, Tiannan Guo*.

Cell. 2025 Dec 11;188(25):7309-7326.e20. doi: 10.1016/j.cell.2025.10.004. Epub 2025 Oct 24. PMID: 41138729.

179

Filter-aided expansion proteomics for the spatial analysis of single cells and organelles in FFPE tissue samples

Zhen Dong#, Chunlong Wu#, Jiayi Chen, Wenhao Jiang, Kiryl D Piatkevich*, Yi Zhu*, Tiannan Guo*.

Nature Protocols. 2025 Oct 9. doi: 10.1038/s41596-025-01256-3. Epub ahead of print. PMID: 41068477.

178

A standardized framework for circulating blood proteomics

Xue Cai, Philipp E. Geyer, Yasset Perez-Riverol, Gilbert S. Omenn, Lianhua Dong, Robert Winkler, Sara Ahadi, Philip Lössl, Xiaobo Yu, Cheng Chang, Markus Ralser, Connie R. Jimenez, Yang Zhao, Yu-Ju Chen, Terence C. W. Poon, Nicolai Bache, Leming Shi, Xinhua Dai, Ziyue Wang, Yi Zhu, Xiang Fang, Jochen M. Schwenk*, Jennifer E. Van Eyk*, Uwe Völker*, Tiannan Guo*.

Nature Genetics. 2025 Oct;57(10):2371-2380. doi: 10.1038/s41588-025-02319-7. Epub 2025 Sep 23. PMID: 40987950.

177

Oncogenic roles of young human de novo genes and their potential as neoantigens in cancer immunotherapy

Chunfu Xiao#, Xiaoge Liu#, Peiyu Liu#, Xinwei Xu, Chao Yao, Chunqiong Li, Qi Xiao, Tiannan Guo, Li Zhang, Yongjun Qian, Chao Wang, Yiting Dong, Yingxuan Wang, Zhi Peng, Chuanhui Han, Qiang Cheng*, Ni A An*, Chuan-Yun Li*.

Cell Genomics. 2025 Jul 14:100928. doi: 10.1016/j.xgen.2025.100928. Epub ahead of print. PMID: 40680745.

176

Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response

Zhang, H.#, L. Hong#, Z. Dong#, S. Xin#, B. Lin, J. Cheng, W. Tian, B. Li, J. Wang, X. Liu, C. Liu, Y. Jin, Y. Feng, G. Su, X. Sun, Q. Liu, X. Dai, Y. Gao, Z. Tong, L. Liu, X. Zhu, Y. Zheng, P. Zhao, T. Guo*, W. Fang* and X. Bao* .

Cell Discovery. 11(1): 60. https://doi.org/10.1038/s41421-025-00811-2. PMID: 40593467

175

MassNet: billion-scale AI-friendly mass spectral corpus enables robust de novo peptide sequencing

Jun A#, Xiang Zhang#, Xiaofan Zhang#, Jiaqi Wei#, Te Zhang, Yamin Deng, Pu Liu, Zongxiang Nie, Yi Chen, Nanqin Dong, Zhiqiang Gao*, Siqi Sun*, Tiannan Guo*.

bioRxiv preprint. 26 June, 2025. https://www.biorxiv.org/content/10.1101/2025.06.20.660691v1

174

Tissue expansion enables proteomics at improved spatial resolution

Zhen Dong#, Wenhao Jiang#, Tiannan Guo*

Trends in Biochemical Sciences. 2025 Oct;50(10):945-946. doi: 10.1016/j.tibs.2025.06.002. Epub 2025 Jun 21. PMID: 40545409.

173

A protein-based classifier for differentiating follicular thyroid adenoma and carcinoma

Yaoting Sun#, He Wang#, Lu Li#, Jianbiao Wang#, Wanyuan Chen#, Li Peng#, Pingping Hu, Jing Yu, Xue Cai, Nan Yao, Yan Zhou, Jiatong Wang, Yingrui Wang, Liqin Qian, Weigang Ge, Mengni Chen, Feng Yang, Zhiqiang Gui, Wei Sun, Zhihong Wang, Minghua Ge, Yi He, Guangzhi Wang, Yongfu Zhao, Huanjie Chen, Xiaohong Wu, Yuxin Du, Wenjun Wei, Fan Wu, Dingcun Luo, Xiangfeng Lin, Haitao Zheng, Xin Zhu, Bei Wei, Jiafei Shen, Jincao Yao, Zhennan Yuan, Tong Liu, Jun Pan, Yifeng Zhang, Yangfan Lv, Qiaonan Guo, Qijun Wu, Tingting Gong, Ting Chen, Shu Zheng, Jingqiang Zhu, Hanqing Liu, Chuang Chen, Hong Han, Sathiyamoorthy Selvarajan, Michael Mingzhao Xing, Kennichi Kakudo, Erik K Alexander, Yijun Wu, Yu Wang, Dong Xu, Hao Zhang, Xiu Nie, Oi Lian Kon, N Gopalakrishna Iyer, Zhiyan Liu, Yi Zhu*, Haixia Guan*, Tiannan Guo*; We-TEC Investigators.

EMBO Molecular Medicine. 2025. 17(7):1519-1538. doi: 10.1038/s44321-025-00242-2. Epub 2025 May 29. PMID: 40442320; PMCID: PMC12254270.

172

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets

Jaco C. Knol#, Mengge Lyu#, Franziska Böttger#, Madalena Nunes Monteiro#, Thang V. Pham, Frank Rolfs, Andrea Vallés-Martí, Tim Schelfhorst, Richard R. de Goeij-de Haas, Irene V. Bijnsdorp, Shuaiyao Wang, Fangfei Zhang, Jun A, Bart A. Westerman, Barbara Sitek, Janne Lehtiö, Jan Koster, Jan N.M. IJzermans, Hanneke W.M. van Laarhoven, Maarten F. Bijlsma, Jan Paul Medema, Alex A. Henneman, Sander R. Piersma, Ruud H. Brakenhoff, Jacqueline Cloos, Valentina Cordo’, Daphne de Jong, Geert Kazemier, Danijela Koppers-Lalic, Mariette Labots, Tessa Y.S. Le Large, John W.M. Martens, Jules P.P. Meijerink, Madiha Mumtaz, Chantal Scheepbouwer, Robby E. Kibbelaar, David P. Noske, Renske D.M. Steenbergen, Nicole C.T. van Grieken, Winan van Houdt, Elisa Giovannetti, Geert J.L.H. van Leenders, Jos Jonkers, Tong Liu, Meisi Yan, Xiaolu Zhan, Tiannan Guo*, Connie R. Jimenez*.

Cancer Cell. 2025 Jul 14;43(7):1328-1346.e8. doi: 10.1016/j.ccell.2025.05.003. Epub 2025 May 29. PMID: 40446800.

171

Proteomic analysis reveals modulation of key proteins in follicular thyroid cancer progression

Xue Cai#, Rui Sun#, Liang Yang#, Nan Yao, Yaoting Sun, Guangmei Zhang, Weigang Ge, Yan Zhou, Zhiqiang Gui, Yu Wang, Haitao Zheng, Dong Xu, Yongfu Zhao, Xiu Nie, Zhiyan Liu, Hao Zhang, Pingping Hu, Honghan Cheng, Zhangzhi Xue, Jiatong Wang, Jing Yu, Chuang Chen, Dingcun Luo, Jingqiang Zhu, Tong Liu, Yifeng Zhang, Qijun Wu, Qiaonan Guo, Wanyuan Chen, Jianbiao Wang, Wenjun Wei, Xiangfeng Lin, Jincao Yao, Guangzhi Wang, Li Peng, Shuyi Liu, Zhihong Wang, Hanqing Liu, Jiaxi Wang, Fan Wu, Zhennan Yuan, Tingting Gong, Yangfan Lv, Jingjing Xiang, Yi Zhu, Lei Xie21, Minghua Ge, Haixia Guan, Tiannan Guo*; We-TEC Investigators.

Chinese Medical Journal. 2025 May 21. doi: 10.1097/CM9.0000000000003645. Epub ahead of print. PMID: 40394764.

170

PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses

Mengling Shi#, Cong Wang#, Zhen Chen#, Yidan Zhou, Liang Yue, Yu Liu, Tiannan Guo, Jun Shang, Haotian Xu, Yu Zhang, Mengcheng Luo*, Caoqi Lei*.

Nature Communications. 2025 May 1;16(1):4084. doi: 10.1038/s41467-025-59421-x. PMID: 40312484; PMCID: PMC12045991.

169

Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus

Yuqi Ying#, Jingquan Lin#, Wei Gao#, Liang Yue#, Qingze Zeng, Katrina Bartas, Dayeon Cheong, Hongjie Jiang, Zhe Zheng, Ligen Shi, An Ping, Yuanjian Fang, Feng Yan, Tiannan Guo, Jianmin Zhang*, Hemmings Wu*, Kevin Beier*, Junming Zhu*, Zhoule Zhu*.

Journal of Advanced Research. 2025 Apr 29:S2090-1232(25)00287-5. doi: 10.1016/j.jare.2025.04.043. Epub ahead of print. PMID: 40311753.

168

Integrative proteogenomic characterization reveals therapeutic targets in poorly differentiated and anaplastic thyroid cancers

Zongfu Pan#, Zhuo Tan#, Ning Xu#, Zhenmei Yao#, Chuanming Zheng, Jinbiao Shang, Lei Xie, Jiajie Xu, Jiafeng Wang, Liehao Jiang, Xuhang Zhu, Dingyi Yu, Ying Li, Yulu Che, Yingying Gong, Zhaoyu Qin, Yiwen Zhang, Xiaozhou Zou, Tong Xu, Zhenying Guo, Tiefeng Jin, Tiannan Guo, Wei Wang, Wanyuan Chen, Yaoting Sun,  Weixin Wang, Xiaojun Peng, Changtian Yin, Chen Ding*, Ping Huang*, Minghua Ge*.

Nature Communications. 2025 Apr 16;16(1):3601. doi: 10.1038/s41467-025-58910-3. PMID: 40234451; PMCID: PMC12000556.

167

The dual-targeted transcription factor BAI1 orchestrates nuclear and plastid gene transcription in land plants

Jing Qin#, Yelin Shan#, Hao Liu, Zhangzhi Xue, Yike Xie, Guoxin Yuan, Yiming Zou, Xiaonuan Hao, Yunpeng Zhu, Xuan Shen, Meng Li, Xu Wang, Puyuan Liu, Jinxiu Xu, Yuhua Wang, Peng Zhao, Yuan Chen, Yi Zhu, Min Xu, Ming Yue, Aigen Fu*, Weiguo Zhang*, Beibei Li*.

Molecular Plant. 2025 Mar 31:S1674-2052(25)00108-X. doi: 10.1016/j.molp.2025.03.018. Epub ahead of print. PMID: 40170352.

166

Grow AI Virtual Cells: Three Data Pillars and Closed-Loop Learning

Liujia Qian, Zhen Dong & Tiannan Guo*.

Cell Research. 2025 May;35(5):319-321. doi: 10.1038/s41422-025-01101-y. PMID: 40128605; PMCID: PMC12012092.

165

Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinoma

Libing Hong#, Jie Mei#, Xuqi Sun#, Yifan Wu#, Zhen Dong#, Yuzhi Jin, Liaoliao Gao, Jinlin Cheng, Weihong Tian, Chuan Liu, Bin Li, Pingping Hu, Lulu Liu, Shan Xin, Xiaomeng Dai, Peng Zhao, Rongping Guo, Minshan Chen, Jingping Yun, Bo Lin*, Wei Wei*, Weijia Fang*, Xuanwen Bao*.

Hepatology. 2025 Feb 25. doi: 10.1097/HEP.0000000000001283. Epub ahead of print. PMID: 39999448.

164

Mass-spectrometry-based proteomics: from single cells to clinical applications

Tiannan Guo*, Judith A. Steen*, Matthias Mann*.

Nature. 2025 Feb;638(8052):901-911. doi: 10.1038/s41586-025-08584-0. Epub 2025 Feb 26. PMID: 40011722.

163

ProteoAutoNet: high-throughput co-eluted protein analysis with robotics and a multi-database search strategy

Mengge Lyu, Yi Chen*, Pingping Hu, Guangmei Zhang, Kunpeng Ma, Xuedong Zhang, Pu Liu, Sai Zhang, Xiangqing Li, Rui Sun*, Tiannan Guo*.

bioRxiv preprint. 23 Feb, 2025. https://doi.org/10.1101/2025.02.18.638804.

162

Strategic priorities for transformative progress in advancing biology with proteomics and artificial intelligence

Yingying Sun, Jun A, Zhiwei Liu, Rui Sun, Liujia Qian, Samuel H. Payne, Wout Bittremieux, Markus Ralser, Chen Li, Yi Chen, Zhen Dong, Yasset Perez-Riverol, Asif Khan, Chris Sander, Ruedi Aebersold, Juan Antonio Vizcaíno, Jonathan R Krieger, Jianhua Yao, Han Wen, Linfeng Zhang, Yunping Zhu, Yue Xuan, Benjamin Boyang Sun, Liang Qiao, Henning Hermjakob, Haixu Tang, Huanhuan Gao, Yamin Deng, Qing Zhong, Cheng Chang, Nuno Bandeira, Ming Li, Weinan E, Siqi Sun, Yuedong Yang, Gilbert S. Omenn, Yue Zhang, Ping Xu, Yan Fu, Xiaowen Liu, Christopher M. Overall, Yu Wang, Eric W. Deutsch, Luonan Chen, Jürgen Cox, Vadim Demichev, Fuchu He, Jiaxing Huang, Huilin Jin, Chao Liu, Nan Li, Zhongzhi Luan, Jiangning Song, Kaicheng Yu, Wanggen Wan, Tai Wang, Kang Zhang, Le Zhang, Peter A. Bell, Matthias Mann*, Bing Zhang*, Tiannan Guo*.

arXiv preprint. 21 Feb 2025. https://doi.org/10.48550/arXiv.2502.15867

161

Spatial distribution of the proteome in human body and cancers

Liang Yue#, Wenhao Jiang#, Sainan Li#, Meng Luo#, Ning Fan, Xiaolu Zhan, Kexin Chen, Tian Lu, Fang Guo, Dongwei Li, Weigang Ge, Zongxiang Nie, Mengge Lyu, Jun A, Yingrui Wang, Yingdan Chen, Zhenhai Fu, Nan Xiang, Lu Li, Fengchao Yu, Guo Ci Teo, Alexy I Nesvizhskii, Meng Wang, Michael P. Snyder, Ben Collins, Ruedi Aebersold, Fei Xu, Yi Zhu*, Tong Liu*, Yan Li*, Tiannan Guo*.

bioRxiv preprint. 18 Feb, 2025. https://doi.org/10.1101/2025.02.14.638212

160

DIA-BERT: pre-trained end-to-end transformer models for enhanced DIA proteomics data analysis

Zhiwei Liu#, Pu Liu#, Yingying Sun#, Zongxiang Nie, Xiaofan Zhang, Yuqi Zhang, Yi Chen*, Tiannan Guo*.

Nature Communications. 2025 Apr 14;16(1):3530. doi: 10.1038/s41467-025-58866-4. PMID: 40229248.

159

Hemithyroidectomy Versus Total Thyroidectomy for Sporadic Medullary Thyroid Cancer: A Chinese Nationwide Large-Scale Cohort Study

Xiao Shi#, Cenkai Shen#, Chuqiao Liu#, Likun Zhang#, Yuxin Du#, Hao Zhang, Hongwei Liu, Jianbiao Wang, Chuang Chen, Yijun Wu, Chunyan Zhang, Zimeng Li, Haitao Tang, Min Yin, Xiaoqi Mao, Shuyi Liu, Yaoting Sun, Yan Zhou, Wenjun Wei, Naisi Huang, Zhihong Wang, Zhiqiang Gui, Hanqing Liu, Jiaxi Wang, Jian Li, Cuiwei Li, Shiyu Xiang, Liang Guo, Yan Zhang, Yi He, Tiannan Guo*, Qinghai Ji*, Zhiyan Liu*, Yu Wang*.

Journal of the National Comprehensive Cancer Network. 2025 Feb 6:1-8. doi: 10.6004/jnccn.2024.7088. Epub ahead of print. PMID: 39919373.

158

iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control.

Huanhuan Gao#, Yi Zhu#*, Dongxue Wang#, Zongxiang Nie#, He Wang#, Guibin Wang, Shuang Liang, Yuting Xie, Yingying Sun, Wenhao Jiang, Zhen Dong, Liqin Qian, Xufei Wang, Mengdi Liang, Min Chen, Houqi Fang, Qiufang Zeng, Jiao Tian, Zeyu Sun, Juan Xue, Shan Li, Chen Chen, Xiang Liu, Xiaolei Lyu, Zhenchang Guo, Yingzi Qi, Ruoyu Wu, Xiaoxian Du, Tingde Tong, Fengchun Kong, Liming Han, Minghui Wang, Yang Zhao, Xinhua Dai, Fuchu He#, Tiannan Guo#

Nature Communications 2025 Jan 21;16(1):892. doi: 10.1038/s41467-024-54871-1. PMID: 39837863; PMCID: PMC11751188.

157

Longitudinal serum proteome mapping reveals biomarkers for healthy ageing and related cardiometabolic diseases

Jun Tang#, Liang Yue#, Ying Xu#, Fengzhe Xu#, Xue Cai, Yuanqing Fu, Zelei Miao, Wanglong Gou, Wei Hu, Zhangzhi Xue, Kui Deng, Luqi Shen, Zengliang Jiang, Menglei Shuai, Xinxiu Liang, Congmei Xiao, Yuting Xie, Tiannan Guo*, Yu-ming Chen* & Ju-Sheng Zheng*.

Nature Metabolism 2025 Jan;7(1):166-181. doi: 10.1038/s42255-024-01185-7. Epub 2025 Jan 13. PMID: 39805987; PMCID: PMC11774760.

156

Comprehensive Mass Spectral Libraries of Human Thyroid Tissues and Cells

Lu Li#, Wenhao Jiang#, Wenjun Wei, Gnana P Krishnamoorthy, Pingping Hu, Mengni Chen, Vera Tiedje, Adrián Acuña-Ruiz, He Wang, Zhihong Wang, Jianbiao Wang, Hanqing Liu, Wanyuan Chen, Haixia Guan, Chuang Chen, Hao Zhang, Yu Wang, James A Fagin, Tiannan Guo, Yi Zhu, Yingrui Wang*, Jianqing Gao*, Yaoting Sun*.

Scientific Data. 2024 Dec 28;11(1):1448. doi: 10.1038/s41597-024-04322-9. PMID: 39732735; PMCID: PMC11682198.

155

AI-driven eyelid tumor classification in ocular oncology using proteomic data.

Linyan Wang#, Xizhe Dai#, Zicheng Liu#, Yaxing Zhao#, Yaoting Sun, Bangxun Mao, Shuohan Wu, Tiansheng Zhu, Fengbo Huang, Nuliqiman Maimaiti#, Xue Cai, Stan Z Li*, Jianpeng Sheng*, Tiannan Guo*, Juan Ye*.

npj Precision Oncology. 2024 Dec 23;8(1):289. doi: 10.1038/s41698-024-00767-8. PMID: 39715816.

154

π-HuB: the proteomic navigator of the human body.

Fuchu He, Ruedi Aebersold, Mark S Baker, Xiuwu Bian, Xiaochen Bo, Daniel W Chan, Cheng Chang, Luonan Chen, Xiangmei Chen, Yu-Ju Chen, Heping Cheng, Ben C Collins, Fernando Corrales, Jürgen Cox, Weinan E, Jennifer E Van Eyk, Jia Fan, Pouya Faridi, Daniel Figeys, George Fu Gao, Wen Gao, Zu-Hua Gao, Keisuke Goda, Wilson Wen Bin Goh, Dongfeng Gu, Changjiang Guo, Tiannan Guo, Yuezhong He, Albert J R Heck, Henning Hermjakob, Tony Hunter, Narayanan Gopalakrishna Iyer, Ying Jiang, Connie R Jimenez, Lokesh Joshi, Neil L Kelleher, Ming Li, Yang Li, Qingsong Lin, Cui Hua Liu, Fan Liu, Guang-Hui Liu, Yansheng Liu, Zhihua Liu, Teck Yew Low, Ben Lu, Matthias Mann, Anming Meng, Robert L Moritz, Edouard Nice, Guang Ning, Gilbert S Omenn, Christopher M Overall, Giuseppe Palmisano, Yaojin Peng, Charles Pineau, Terence Chuen Wai Poon, Anthony W Purcell, Jie Qiao, Roger R Reddel, Phillip J Robinson, Paola Roncada, Chris Sander, Jiahao Sha, Erwei Song, Sanjeeva Srivastava, Aihua Sun, Siu Kwan Sze, Chao Tang, Liujun Tang, Ruijun Tian, Juan Antonio Vizcaíno, Chanjuan Wang, Chen Wang, Xiaowen Wang, Xinxing Wang, Yan Wang, Tobias Weiss, Mathias Wilhelm, Robert Winkler, Bernd Wollscheid, Limsoon Wong, Linhai Xie, Wei Xie, Tao Xu, Tianhao Xu, Liying Yan, Jing Yang, Xiao Yang, John Yates, Tao Yun, Qiwei Zhai, Bing Zhang, Hui Zhang, Lihua Zhang, Lingqiang Zhang, Pingwen Zhang, Yukui Zhang, Yu Zi Zheng, Qing Zhong, Yunping Zhu & π-HuB Consortium.

Nature. 2024 Dec;636(8042):322-331. doi: 10.1038/s41586-024-08280-5. Epub 2024 Dec 11. Erratum in: Nature. 2024 Dec 23. doi: 10.1038/s41586-024-08555-x. PMID: 39663494.

153

Association of the EAT-Lancet diet, serial measures of serum proteome and gut microbiome, and cardiometabolic health: a prospective study of Chinese middle-aged and elderly adults

Kui Deng#, Luqi Shen#, Zhangzhi Xue#, Bang-yan Li#, Jun Tang, Hui Zhao, Fengzhe Xu, Zelei Miao, Xue Cai, Wei Hu, Yuanqing Fu, Zengliang Jiang, Xinxiu Liang, Congmei Xiao, Menglei Shuai, Wanglong Gou, Liang Yue, Yuting Xie, Ting-yu Sun, Tiannan Guo, Yu-ming Chen*, Ju-Sheng Zheng*.

The American Journal of Clinical Nutrition. In press. https://doi.org/10.1016/j.ajcnut.2024.10.011

152

Integral-Omics: Serial Extraction and Profiling of Metabolome, Lipidome, Genome, Transcriptome, Whole Proteome and Phosphoproteome Using Biopsy Tissue

Wei Li, Jing Sun, Rui Sun, Yujuan Wei, Junke Zheng*, Yi Zhu*, Tiannan Guo*.

Analytical Chemistry. 2025 Jan 7. doi: 10.1021/acs.analchem.4c04421. Epub ahead of print. PMID: 39772508.

151

Mitochondrial Proteome Defined Molecular Pathological Characteristics of Oncocytic Thyroid Tumors

Lu Li, Likun Zhang, Wenhao Jiang, Zhiqiang Gui, Zhihong Wang, Hao Zhang, Yi He, Yi Zhu, Tiannan Guo, Haixia Guan*, Zhiyan Liu*, Yaoting Sun*, Jianqing Gao*.

Endocr Pathol. 2024 Nov 4. doi: 10.1007/s12022-024-09834-z. Epub ahead of print. PMID: 39495444.

150

Proteomic profiling of gliomas unveils immune and metabolism-driven subtypes with implications for anti-nucleotide metabolism therapy

Jinsen Zhang#, Rui Sun#, Yingying Lyu#, Chaxian Liu#, Ying Liu, Yuan Feng, Minjie Fu, Peter Jih Cheng Wong, Zunguo Du, Tianming Qiu, Yi Zhang, Dongxiao Zhuang, Zhiyong Qin, Yu Yao, Wei Zhu, Tiannan Guo, Wei Hua*, Hui Yang*, Ying Mao*.

Nature Communications. 2024 Nov 19;15(1):10005. doi: 10.1038/s41467-024-54352-5. PMID: 39562821.

149

AI-empowered perturbation proteomics for complex biological systems

Liujia Qian, Rui Sun, Ruedi Aebersold, Peter Bühlmann, Chris Sander*, Tiannan Guo*.

Cell Genomics. 2024 Nov 13;4(11):100691. doi: 10.1016/j.xgen.2024.100691. Epub 2024 Nov 1. PMID: 39488205; PMCID: PMC11605689.