Yingrui obtained her PhD degree from Tsinghua University, School of Life Sciences, and majored in Biology (2013-2019). During her doctoral study, she mainly focused on the mechanism of flagellar length control, especially by LF4, a MAPK-related kinase, also used the proteomics analysis and comparative phosphorylation proteomics to further explore LF4 associated proteins. From July 2019 to December 2020, she worked in the Yangtze Delta Region Research Institute of Tsinghua University in Zhejiang province. In January 2021, she joined the Guomics team as a postdoctoral researcher for proteomic big data research. Yingrui joined iMarker Lab as a research assistant professor in January 2023 and became a research associate professor in September 2024.
Representative Publications
Yan Zhou#, Yingrui Wang#, Xiao Shi#, Jiatong Wang#, Zelin Zang*, Likun Zhang#, Zhiqiang Gu, Xue Cai, Pingping Hu, Jiaxi Wang, Hanqing Liu, Zhihong Wang, Haixia Guan, Xiaohong Wu, Cenkai Shen, Yi He, Mo Li, Hao Zhang, Jianbiao Wang , Yijun Wu, Chuang Chen , Yi Zhu, Yaoting Sun*, Zhiyan Liu*, Yu Wang*, Tiannan Guo*. Multi-center multi-omics integration predicts individualized prognosis in medullary thyroid carcinoma. Nature Communications. 2026, 17, 432.
Tian Lu#, Yuting Xie#, Yingrui Wang, Xiling Lin, Xue Cai, Yuqi Zhang, Zongxiang Nie, Chang Su, Wanglong Gou, Hong Zhang, Jing Wang, Yan Zhong, Zeyin Lai, Jingjing Xiang, Peng-Fei Shan, Ju-Sheng Zheng, Huijun Wang, Yi Zhu*, Tiannan Guo*. Protein restriction reprograms the multi-organ proteomic landscape of mouse aging. Cell. 2025, Oct 24:S0092-8674(25)01133-X.
Lu Li#, Wenhao Jiang#, Wenjun Wei, Gnana P Krishnamoorthy, Pingping Hu, Mengni Chen, Vera Tiedje, Adrián Acuña-Ruiz, He Wang, Zhihong Wang, Jianbiao Wang, Hanqing Liu, Wanyuan Chen, Haixia Guan, Chuang Chen, Hao Zhang, Yu Wang, James A Fagin, Tiannan Guo, Yi Zhu, Yingrui Wang*, Jianqing Gao*, Yaoting Sun*.Comprehensive Mass Spectral Libraries of Human Thyroid Tissues and Cells. Scientific Data, 2024,11(1):1448.
Yingrui Wang#, Qianru Zhu#, Rui Sun#, Xiao Yi#, Lingling Huang, Yifan Hu, Weigang Ge, Huanhuan Gao, Xinfu Ye, Yu Song, Li Shao,Yantao Li, Jie Li*, Tiannan Guo*, Junping Shi*. Longitudinal proteomic investigation of COVID-19 vaccination. Protein&Cell, 2023, 14(9): 668-682.
Hong Wang*,#, Cuicui Liu#, Xiaowei Xie#, Mingming Niu#, Yingrui Wang#, Xueliang Cheng#, Biao Zhang#, Dong Zhang, Mengyao Liu, Rui Sun, Yezi Ma, Shihui Ma , Huijun Wang, Guoqing Zhu, Yang Lu,Baiming Huang, Pei Su, Xiaoyuan Chen, Jingjing Zhao, Hongtao Wang, Long Shen, Lixia Fu, Qianqian Huang, Yang Yang, He Wang, Chunlong Wu, Weigang Ge, Chen Chen, Qianyu Huo, Qingping Wang, Ying Wang, Li Geng, Yan Xie, Yi Xie, Lijun Liu, Jianwei Qi, Huaiyong Chen, Junping Wu, Erlie Jiang, Wentao Jiang, Ximo Wang∗, Zhongyang Shen∗, Tiannan Guo∗, Jiaxi Zhou∗, Ping Zhu∗, Tao Cheng∗. Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection. Immunity, 2023, 56(6): 1410-1428. (2023 Top Ten Best Achievements in Chinese Hematology Research)
Yingrui Wang#, Yahui Ren, Junmin Pan. Regulation of flagellar assembly and length in Chlamydomonas by LF4, a MAPK-related kinase. The FASEB Journal. 2019, 33(5): 6431-6441.
Tian Lu#, Yingrui Wang, Tiannan Guo. Multi-omics in COVID-19: Seeing the unseen but overlooked in the clinic. Cell Reports Medicine. 2022. DOI: 10.1016/j.xcrm.2022.100580.
Xiao Liang*, Yingrui Wang, Tiannan Guo. Proteomics approaches to long COVID: status and outlooks. Life Medicine, 2023, 2(3): 1-3.
Rui Sun#, Jun A#, Haolan Yu#, Yan Wang#, Miaoxia He#, Lingling Tan, Honghan Cheng, Jili Zhang, Yingrui Wang, Xiaochen Sun, Mengge Lyu, Min Qu, Lingling Huang, Zijian Li, Wenhui Zhang, Kunpeng Ma, Zhenyang Dong, Weigang Ge, Yun Zhang, Xuan Ding, Bo Yang, Jianguo Hou, Chuanliang Xu, Linhui Wang, Yi Zhu, Tiannan Guo*, Xu Gao*, Chenghua Yang*. Cell Reports Medicine. 2024. Proteomic landscape profiling of primary prostate cancer reveals a 16-ptotein panel for prognosis prediction (Accepted).
Rui Sun#, Mengge Lyu, Shuang Liang, Weigang Ge, Yingrui Wang, Xuan Ding, Cheng Zhang, Yan Zhou, Shanjun Chen, Lirong Chen, Tiannan Guo. A prostate cancer tissue specific spectral library for targeted proteomic analysis. Proteomics. 2021. DOI: 10.1002/pmic.202100147.
In preparation
Xi Zheng#, Yingrui Wang#, He Wang#, Wanmao Ni, Wei Dai, Yaoting Sun, Jiatong Wang, Shu Zheng, Kefeng Ding, Yeting Hu*, Tiannan Guo*, Ting Chen*. A Plasma Protein Classifier to Predict Colorectal Cancer and its Liver Metastasis. 2024 (Submitted).
Patents
Granted patents:
Tiannan Guo; Xiao Liang; Yingqiu Shi; Yingrui Wang; A method for efficiently removing peptide carryover in liquid chromatography and its application. 2022-11-11, China, ZL202210103388.2 (granted patent).
Tao Cheng; Hong Wang; Yingrui Wang;; Tiannan Guo; Mingming Niu; Jiaxi Zhou; Ximo Wang; Wentao Jiang; He Wang; Jianwei Qi; Lijun Liu; Junping Wu; Yan Xie; Shihui Ma. Application of reagents for measuring biomarker levels in samples to predict the risk of recurrent Omicron test positivity, with metabolite, protein and combined models. 2022-11-25, China, ZL202211016042.5 (granted patent).
Kefeng Ding; Tiannan Guo; Ting Chen; Xi Zheng; He Wang; Yingrui Wang;; Yeting Hu. Application of a protein biomarker panel in the preparation of products for early diagnosis of colorectal cancer. 2024-03-14, China, ZL202410294264.6 (granted patent).
Tiannan Guo; Junping Shi; Yingrui Wang; Qianru Zhu; Yifan Hu; Li Shao. Protein biomarkers for predicting populations with different immune responses after COVID-19 vaccination and their application. 2024-10-18, China, ZL202210299567.8 (granted patent).
Patent applications:
Tiannan Guo; Kefeng Ding; Yingrui Wang; Ting Chen; Xi Zheng; He Wang; Yeting Hu. A biomarker panel, kit, system and their applications for predicting liver metastasis in colorectal cancer. 2024-05-17, China, CN202410618368.8 (patent application submitted).
Grants
Yingrui Wang, National Natural Science Foundation of China (Young Scientist Fund): Proteomic big data and machine learning empowered research on host immune responses before and after COVID-19 vaccination (Grant No. 32200763), January 2023–December 2025 (principal investigator; completed).
“Pioneer” and “Leading Goose” R&D Program of Zhejiang: AI empowered multi-omics for early screening and diagnosis of lung cancer (Grant No. 2023C03056), January 2023–December 2025 (participant; listed as ongoing in the source profile).
The Key Research and Development Program of Zhejiang Province: Mass cytometry-based cellular analysis (Grant No. 2022C03037), January 2022–December 2023 (participant; completed).