Xue received her training in analytical chemistry from Zhejiang University of Technology (2011-2018), specializing in chromatography and mass spectrometry. She joined the Guomics lab as a research assistant in April 2018 and was awarded for outstanding performance at Westlake University in 2019. Pursuing her academic career, Xue began her PhD in the Guomics lab in August 2021, completed her doctorate in June 2025, and immediately transitioned to a postdoctoral position in July 2025. Her research focuses on developing and optimizing proteomics methods, clinical proteomics research, and translational medicine, bridging cutting-edge techniques with practical clinical applications.
Representative Publications:
[Note: #, co-first author; *co-corresponding]
- Xue Cai#, Zhangzhi Xue#, et al., Tiannan Guo*. Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome. Cell Rep Med, 2023. 4(9): p. 101172.
- Xue Cai, Zhangzhi Xue, et al., Tiannan Guo*. High-throughput proteomic sample preparation using pressure cycling technology. Nature Protocols, 2022. 17(10): p. 2307-2325.
- Xue Cai#, Weigang Ge#, et al., Yi Zhu*, Tiannan Guo*. PulseDIA: Data-Independent Acquisition Mass Spectrometry Using Multi-Injection Pulsed Gas-Phase Fractionation. J Proteome Res, 2021. 20(1): p. 279-288.
- Qing-Qing Tao#, Xue Cai#, et al., Tiannan Guo*, Zhi-Ying Wu*. Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling. The Innovation, 2024. 5(1): p. 100544.
- Ying Zhang#, Xue Cai#, et al., Yi Zhu*, Tiannan Guo*. Potential Use of Serum Proteomics for Monitoring COVID-19 Progression to Complement RT-PCR Detection. J Proteome Res, 2022. 21(1): p. 90-100.
- Jinjian Xu#, Xue Cai#, et al., Tiannan Guo*, Yu-ming Chen*. Proteome-wide profiling reveals dysregulated molecular features and accelerated aging in osteoporosis: A 9.8-year prospective study. Aging Cell, 2023: p. e14035.
- Fengzhe Xu#, Evan Yi-Wen Yu#, Xue Cai#, et al., Tiannan Guo*, Ju-Sheng Zheng*. Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility. Nat Commun, 2023. 14(1): p. 896.
- Wanglong Gou#, Yuanqing Fu#, Liang Yue#, Geng-Dong Chen#, Xue Cai#, et al., Tiannan Guo*, Ju-Sheng Zheng*. Gut microbiota, inflammation, and molecular signatures of host response to infection. J Genet Genomics, 2021. 48(9): p. 792-802.
Oral talks/posters
2023.09, Human Proteome Organization (HUPO) conference; Busan, South Korea; Poster: Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome.
2023.09, CNHUPO; Chengdu, China; Oral presentation: Preoperative diagnosis of thyroid nodules using a novel multi-omics classifier test.
2023.09, China Proteomics Conference; Chengdu, China; Excellent poster: Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome.
2019.12, 9th Zhejiang Analysis and Testing Association Academic Conference; Oral presentation: PulseDIA: in-depth data independent acquisition mass spectrometry using enhanced gas phase fractionation.
Patents:
- A proteomics method using pulsed data-independent acquisition mass spectrometry; Tiannan Guo, Yi Zhu, Xue Cai, Weigang Ge
- Protein biomarkers for predicting the probability of developing metabolic syndrome over a future period and their applications; Tiannan Guo, Ju-Sheng Zheng, Yu-ming Chen, Xue Cai, Bo Wang.
- A proteomics method integrating targeted and untargeted approaches; Tiannan Guo, Xue Cai, Weigang Ge.
Academic Awards
2021-2022 academic year, Suwu Scholarship
2022-2023 academic year, Yiqiao First-class Scholarship
2021-2022, 2022-2023 academic year, Zhejiang University Outstanding Graduate, Zhejiang University Excellent Graduate
2020.01, Westlake University 2019 Advanced Worker
2019.12, Third Prize for Excellent Paper at the 9th Zhejiang Province Analytical Testing Academic Conference
2017-2018: Zhejiang University of Technology Outstanding Graduate at the university level (Ranking 1/15 in comprehensive performance)
2016-2017: Zhejiang University of Technology First-class Academic Scholarship at the university level (Ranking 34/179 in comprehensive performance), Social Work Award, Outstanding Graduate Cadre
2015-2016: Zhejiang University of Technology “Xin’an Chemical” Enterprise Scholarship (Ranking 17/195 in comprehensive performance), First-class Academic Scholarship at the university level, Outstanding League Cadre
2013-2014: Zhejiang University of Technology Social Work Award, Outstanding League Cadre