Selected publications

140

Proteomic landscape of epithelial ovarian cancer

Liujia Qian#, Jianqing Zhu#, Zhangzhi Xue#, Yan Zhou#, Nan Xiang#, Hong Xu#, Rui Sun, Wangang Gong, Xue Cai, Lu Sun, Weigang Ge, Yufeng Liu, Ying Su, Wangmin Lin, Yuecheng Zhan, Junjian Wang, Shuang Song, Xiao Yi, Maowei Ni, Yi Zhu*, Yuejin Hua*, Zhiguo Zheng*, Tiannan Guo*.

Nature Communications. 2024 Jul 31;15(1):6462. doi: 10.1038/s41467-024-50786-z. PMID: 39085232.

120

Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome

Xue Cai#, Zhangzhi Xue#, Fang-Fang Zeng#, Jun Tang#, Liang Yue#, Bo Wang#, Weigang Ge, Yuting Xie, Zelei Miao, Wanglong Gou, Yuanqing Fu, Sainan Li, Jinlong Gao, Menglei Shuai, Ke Zhang, Fengzhe Xu, Yunyi Tian, Nan Xiang, Yan Zhou, Peng-Fei Shan, Yi Zhu*, Yu-ming Chen*, Ju-Sheng Zheng*, Tiannan Guo*

Cell Reports Medicine. 2023 Sep 19;4(9). doi: https://doi.org/10.1016/j.xcrm.2023.101172. PMID: 37652016.

113

Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets

Rui Sun#, Weigang Ge#, Yi Zhu#, Azin Sayad#, Augustin Luna, Mengge Lyu, Shuang Liang, Luis Tobalina, Vinodh N. Rajapakse, Chenhuan Yu, Huanhuan Zhang, Jie Fang, Fang Wu, Hui Xie, Julio Saez-Rodriguez, Huazhong Ying, William C. Reinhold, Chris Sander, Yves Pommier, Benjamin G. Neel*, Ruedi Aebersold*, Tiannan Guo*

Molecular & Cellular Proteomics. 2023 Jun 19:100602. doi.org/10.1016/j.mcpro.2023.100602. PMID: 37343696.

100

Longitudinal proteomic investigation of COVID-19 vaccination

Yingrui Wang#, Qianru Zhu#, Rui Sun#, Xiao Yi#, Lingling Huang, Yifan Hu, Weigang Ge, Huanhuan Gao, Xinfu Ye, Yu Song, Li Shao, Yantao Li, Jie Li*, Tiannan Guo*, Junping Shi*

Protein & Cell. 2023 Sep 14;14(9):668-682. doi: 10.1093/procel/pwad004. PMID: 36930526.

96

Spatially resolved proteomics via tissue expansion

Lu Li#, Cuiji Sun#, Yaoting Sun#, Zhen Dong#, Runxin Wu, Xiaoting Sun, Hanbin Zhang, Wenhao Jiang, Yan Zhou, Xufeng Cen, Shang Cai, Hongguang Xia, Yi Zhu, Tiannan Guo* & Kiryl D. Piatkevich*

Nature Communications. 2022 Nov 30;13(1):7242. doi: 10.1038/s41467-022-34824-2. PMID: 36450705.

89

Artificial intelligence defines protein-based classification of thyroid nodules

Yaoting Sun#, Sathiyamoorthy Selvarajan#, Zelin Zang#, Wei Liu#, Yi Zhu#, Hao Zhang#, Wanyuan Chen, Hao Chen, Lu Li, Xue Cai, Huanhuan Gao, Zhicheng Wu, Yongfu Zhao, Lirong Chen, Xiaodong Teng, Sangeeta Mantoo, Tony Kiat-Hon Lim, Bhuvaneswari Hariraman, Serene Yeow, Syed Muhammad Fahmy bin Syed Abdillah, Sze Sing Lee, Guan Ruan, Qiushi Zhang, Tiansheng Zhu, Yifan Hu, Zhen Dong, Weigang Ge, Qi Xiao, Weibin Wang, Guangzhi Wang, Junhong Xiao, Yi He, Zhihong Wang, Wei Sun, Yuan Qin, Jiang Zhu, Xu Zheng, Linyan Wang, Xi Zheng, Kailun Xu, Yingkuan Shao, Shu Zheng, Kexin Liu, Ruedi Aebersold, Haixia Guan, Xiaohong Wu, Dingcun Luo, Wen Tian, Stan Z. Li*, Oi Lian Kon*, N. Gopalakrishna Iyer*, Tiannan Guo*.

Cell Discovery. 2022 Sep 6;8(1):85. doi: 10.1038/s41421-022-00442-x. Erratum in: Cell Discov. 2022 Sep 30;8(1):100. PMID: 36068205.

88

Tissue-characteristic Expression of Mouse Proteome

Tian Lu, Liujia Qian, Yuting Xie, Qiushi Zhang, Wei Liu, Weigang Ge, Yi Zhu *, Lijia Ma *, Cheng Zhang *, Tiannan Guo *.

Molecular & Cellular Proteomics. 2022 Oct;21(10):100408. doi: 10.1016/j.mcpro.2022.100408. PMID: 36058520.

83

Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding

Shaohua Tang# , Rui Sun# , Weigang Ge# , Tingting Mao# , Liujia Qian# , Chongquan Huang# , Zhouyang Kang# , Qi Xiao , Meng Luo , Qiushi Zhang , Sainan Li , Hao Chen , Wei Liu , Bingjie Wang , Shufei Li , Xiaoling Lin , Xueqin Xu , Huanzheng Li , Lianpeng Wu , Jianyi Dai , Huanhuan Gao , Lu Li , Tian Lu , Xiao Liang , Xue Cai , Guan Ruan , Fei Xu , Yan Li , Yi Zhu* , Ziqing Kong*, Jianping Huang *, Tiannan Guo*.

Cell Discovery. 2022 Jul 25;8(1):70. doi: 10.1038/s41421-022-00441-y. PMID: 35879274.

62

SnapShot: Clinical proteomics

Yi Zhu, Ruedi Aebersold, Matthias Mann, Tiannan Guo.

Cell. 2021 Sep 2;184(18):4840-4840.e1. doi: 10.1016/j.cell.2021.08.015. PMID: 34478659.

53

Multi-organ Proteomic Landscape of COVID-19 Autopsies

Xiu Nie#, Liujia Qian#, Rui Sun#, Bo Huang#, Xiaochuan Dong#, Qi Xiao#, Qiushi Zhang#, Tian Lu, Liang Yue, Shuo Chen, Xiang Li, Yaoting Sun, Li Lu, Luang Xu, Li Yan, Ming Yang, Zhangzhi Xue, Shuang Liang, Xuan Ding, Chunhui Yuan, Li Peng, Wei Liu, Xiao Yi, Mengge Lyu, Guixiang Xiao, Xia Xu, Weigang Ge, Jiale He, Jun Fan, Junhua Wu, Meng Luo, Xiaona Chang, Huaxiong Pan, Xue Cai, Junjie Zhou, Jing Yu, Huanhuan Gao, Mingxing Xie, Sihua Wang, Guan Ruan, Hao Chen, Hua Su, Heng Mei, Danju Luo, Dashi Zhao, Fei Xu, Yan Li, Yi Zhu*, Jiahong Xia*, Yu Hu*, Tiannan Guo*.

Cell. 2021 Feb.184(3): 775-791.e14. doi: 10.1016/j.cell.2021.01.004. PMID: 33503446.

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

Bo Shen #, Xiao Yi #, Yaoting Sun #, Xiaojie Bi #, Juping Du #, Chao Zhang #, Sheng Quan #, Fangfei Zhang, Rui Sun, Liujia Qian, Weigang Ge, Wei Liu, Shuang Liang, Hao Chen, Ying Zhang, Jun Li, Jiaqin Xu, Zebao He, Baofu Chen, Jing Wang, Haixi Yan, Yufen Zheng, Donglian Wang, Jiansheng Zhu, Ziqing Kong, Zhouyang Kang, Xiao Liang, Xuan Ding, Guan Ruan, Nan Xiang, Xue Cai, Huanhuan Gao, Lu Li, Sainan Li, Qi Xiao, Tian Lu, Yi Zhu*, Huafen Liu*, Haixiao Chen*, Tiannan Guo*.

Cell. 2020 Jul 9;182(1):59-72.e15. doi: 10.1016/j.cell.2020.05.032. PMID: 32492406.

37

High-throughput Proteomic analysis of FFPE tissue samples facilitates tumor stratification

Yi Zhu#, Tobias Weiss#, Qiushi Zhang, Rui Sun, Bo Wang, Xiao Yi, Zhicheng Wu, Huanhuan Gao, Xue Cai, Guan Ruan, Tiansheng Zhu, Chao Xu, Sai Lou, Xiaoyan Yu, Ludovic Gillet, Peter Blattmann, Karim Saba, Christian D. Fankhauser, Michael B. Schmid, Dorothea Rutishauser, Jelena Ljubicic, Ailsa Christiansen, Christine Fritz, Niels J. Rupp, Cedric Poyet, Elisabeth Rushing, Michael Weller, Patrick Roth, Eugenia Haralambieva, Silvia Hofer, Chen Chen, Wolfram Jochum, Xiaofei Gao, Lirong Chen, Qing Zhong, Peter J. Wild*, Ruedi Aebersold*, Tiannan Guo*.

Molecular Oncology. 2019 Sep;13(11): 2305-2328. doi: 10.1002/1878-0261.12570. PMID: 31495056.

All publications

150

A diagnostic protein assay for differentiating follicular thyroid adenoma and carcinoma

Yaoting Sun#, He Wang#, Lu Li#, Jianbiao Wang#, Wanyuan Chen#, Li Peng#, Pingping Hu, Jing Yu, Xue Cai, Nan Yao, Yan Zhou, Jiatong Wang, Yingrui Wang, Liqin Qian, Weigang Ge, Mengni Chen, Feng Yang, Zhiqiang Gui, Wei Sun, Zhihong Wang, Minghua Ge, Yi He, Guangzhi Wang, Yongfu Zhao, Huanjie Chen, Xiaohong Wu, Yuxin Du, Wenjun Wei, Fan Wu, Dingcun Luo, Xiangfeng Lin, Haitao Zheng, Xin Zhu, Bei Wei, Jiafei Shen, Jincao Yao, Zhennan Yuan, Tong Liu, Jun Pan, Yifeng Zhang, Yangfan Lv, Qiaonan Guo, Qijun Wu, Tingting Gong, Ting Chen, Shu Zheng, Jingqiang Zhu, Hanqing Liu, Chuang Chen, Hong Han, Sathiyamoorthy Selvarajan, Mingzhao Xing, Kennichi Kakudo, Erik K. Alexander, Yijun Wu, Yu Wang, Dong Xu, Hao Zhang, Xiu Nie, Oi Lian Kon, N. Gopalakrishna Iyer, Zhiyan Liu, Yi Zhu*, Haixia Guan*, Tiannan Guo*, We-TEC Investigators.

MedRxiv, September 2024. doi: https://doi.org/10.1101/2024.09.26.24314403

142

Proteomic landscape profiling of primary prostate cancer reveals a 16-protein panel for prognosis prediction

Rui Sun#, Jun A#, Haolan Yu#, Yan Wang#, Miaoxia He#, Lingling Tan, Honghan Cheng, Jili Zhang, Yingrui Wang, Xiaochen Sun, Mengge Lyu, Min Qu, Lingling Huang, Zijian Li, Wenhui Zhang, Kunpeng Ma, Zhenyang Dong, Weigang Ge, Yun Zhang, Xuan Ding, Bo Yang, Jianguo Hou, Chuanliang Xu, Linhui Wang, Yi Zhu, Tiannan Guo*, Xu Gao*, Chenghua Yang*. Proteomic landscape profiling of primary prostate cancer reveals a 16-protein panel for prognosis prediction.

Cell Reports Medicine. 2024 Aug 20; 5(8):101679. Doi: https://doi.org/10.1016/j.xcrm.2024.101679. PMID: 39168102.

140

Proteomic landscape of epithelial ovarian cancer

Liujia Qian#, Jianqing Zhu#, Zhangzhi Xue#, Yan Zhou#, Nan Xiang#, Hong Xu#, Rui Sun, Wangang Gong, Xue Cai, Lu Sun, Weigang Ge, Yufeng Liu, Ying Su, Wangmin Lin, Yuecheng Zhan, Junjian Wang, Shuang Song, Xiao Yi, Maowei Ni, Yi Zhu*, Yuejin Hua*, Zhiguo Zheng*, Tiannan Guo*.

Nature Communications. 2024 Jul 31;15(1):6462. doi: 10.1038/s41467-024-50786-z. PMID: 39085232.

134

Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities

Yi-Zhou Jiang#, Ding Ma#, Xi Jin#, Yi Xiao#, Ying Yu#, Jinxiu Shi#, Yi-Fan Zhou, Tong Fu, Cai-Jin Lin, Lei-Jie Dai, Cheng-Lin Liu, Shen Zhao, Guan-Hua Su, Wanwan Hou, Yaqing Liu, Qingwang Chen, Jingcheng Yang, Naixin Zhang, Wen-Juan Zhang, Wei Liu, Weigang Ge, Wen-Tao Yang, Chao You, Yajia Gu, Virginia Kaklamani, François Bertucci, Claire Verschraegen, Anneleen Daemen, Nakul M. Shah, Ting Wang, Tiannan Guo, Leming Shi, Charles M. Perou, Yuanting Zheng*, Wei Huang* & Zhi-Ming Shao*

Nature Cancer. 2024 Apr;5(4):673-690. doi: 10.1038/s43018-024-00725-0. Epub 2024 Feb 12. PMID: 38347143.

133

The 2023 Report on the Proteome from the HUPO Human Proteome Project

Gilbert S Omenn, Lydie Lane, Christopher M Overall, Cecilia Lindskog, Charles Pineau, Nicolle H Packer, Ileana M Cristea, Susan T Weintraub, Sandra Orchard, Michael H A Roehrl, Edouard Nice, Tiannan Guo, Jennifer E Van Eyk, Siqi Liu, Nuno Bandeira, Ruedi Aebersold, Robert L Moritz, Eric W Deutsch.

Journal of Proteome Research.  2024 Jan 17. doi: 10.1021/acs.jproteome.3c00591. Epub ahead of print. PMID: 38232391.

129

Risk stratification of papillary thyroid cancers using multidimensional machine learning

Li, Yuanhui#; Wu, Fan#; Ge, Weigang#; Zhang, Yu #; Hu, Yifan; Zhao, Lingqian; Gou, Wanglong; Shi, Jingjing; Ni, Yeqin; Li, Lu; Fu, Wenxin; Lin, Xiangfeng; Yu, Yunxian; Han, Zhijiang; Chen, Chuanghua; Xu, Rujun; Zhang, Shirong; Zhou, Li; Pan, Gang; Peng, You; Mao, Linlin; Zhou, Tianhan; Zheng, Jusheng; Zheng, Haitao*; Sun, Yaoting*; Guo, Tiannan*; Luo, Dingcun*

International Journal of Surgery. 2024 Jan 1;110(1):372-384. doi: 10.1097/JS9.0000000000000814. PMID: 37916932.

126

Proteomic-based stratification of intermediate-risk prostate cancer patients

Qing Zhong#, Rui Sun#, Adel T Aref# , Zainab Noor#, Asim Anees#, Yi Zhu, Natasha Lucas,Rebecca C Poulos, Mengge Lyu, Tiansheng Zhu, Guo-Bo Chen , Yingrui Wang, Xuan Ding, Dorothea Rutishauser, Niels J Rupp, Jan H Rueschoff, Cédric Poyet, Thomas Hermanns, Christian Fankhauser, María Rodríguez Martínez, Wenguang Shao, Marija Buljan, Janis Frederick Neumann, Andreas Beyer, Peter G Hains, Roger R Reddel , Phillip J Robinson, Ruedi Aebersold*, Tiannan Guo*, Peter J Wild*

Life Science Alliance. 2023 Dec 4;7(2):e202302146. doi: 10.26508/lsa.202302146. PMID: 38052461.

125

Multitissue Circadian Proteome Atlas of WT and Per1-/-/Per2-/- mice

Liujia Qian#, Yue Gu#, Qiaocheng Zhai#, Zhangzhi Xue#, Youqi Liu, Sainan Li, Yizhun Zeng, Rui Sun, Qiushi Zhang, Xue Cai, Weigang Ge, Zhen Dong, Huanhuan Gao, Yan Zhou, Yi Zhu*, Ying Xu*, Tiannan Guo*

Molecular & Cellular Proteomics. 2023 Dec;22(12):100675. doi: 10.1016/j.mcpro.2023.100675. PMID: 37940002.

124

Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation

Pazhanichamy Kalailingam, Khalilatul-Hanisah Mohd-Kahliab, SoFong Cam Ngan, Ranjith Iyappan, Evelin Melekh, Tian Lu, Gan Wei Zien, Bhargy Sharma, Tiannan Guo, Adam J MacNeil, Rebecca EK MacPherson, Evangelia Litsa Tsiani, Deborah D O’Leary, Kah Leong Lim, I Hsin Su, Yong-Gui Gao, A Mark Richards, Raj N Kalaria, Christopher P Chen, Neil E McCarthy & Siu Kwan Sze

EMBO Molecular Medicine. 2023 Dec 7;15(12):e18526. doi: 10.15252/emmm.202318526. PMID: 37971164.

121

Forager-farmer transition at the crossroads of East and Southeast Asia 4900 years ago

Minmin Ma#, Minxia Lu#, Rui Sun#, Zhonghua Zhu#, Dorian Q. Fuller, Jianxin Guo, Guanglin He, Xiaomin Yang, Lingling Tan, Yongxiu Lu, Jiajia Dong, Ruiliang Liu, Jishuai Yang, Bo Li, Tiannan Guo, Xiaorui Li, Dongyue Zhao, Ying Zhang, Chuan-Chao Wang*, Guanghui Dong*

Science Bulletin. 2024 Jan 15;69(1):103-113. doi: 10.1016/j.scib.2023.10.015. Epub 2023 Oct 16. PMID: 37914610.

120

Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome

Xue Cai#, Zhangzhi Xue#, Fang-Fang Zeng#, Jun Tang#, Liang Yue#, Bo Wang#, Weigang Ge, Yuting Xie, Zelei Miao, Wanglong Gou, Yuanqing Fu, Sainan Li, Jinlong Gao, Menglei Shuai, Ke Zhang, Fengzhe Xu, Yunyi Tian, Nan Xiang, Yan Zhou, Peng-Fei Shan, Yi Zhu*, Yu-ming Chen*, Ju-Sheng Zheng*, Tiannan Guo*

Cell Reports Medicine. 2023 Sep 19;4(9). doi: https://doi.org/10.1016/j.xcrm.2023.101172. PMID: 37652016.

113

Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets

Rui Sun#, Weigang Ge#, Yi Zhu#, Azin Sayad#, Augustin Luna, Mengge Lyu, Shuang Liang, Luis Tobalina, Vinodh N. Rajapakse, Chenhuan Yu, Huanhuan Zhang, Jie Fang, Fang Wu, Hui Xie, Julio Saez-Rodriguez, Huazhong Ying, William C. Reinhold, Chris Sander, Yves Pommier, Benjamin G. Neel*, Ruedi Aebersold*, Tiannan Guo*

Molecular & Cellular Proteomics. 2023 Jun 19:100602. doi.org/10.1016/j.mcpro.2023.100602. PMID: 37343696.

110

Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection

Hong Wang#*, Cuicui Liu#, Xiaowei Xie#, Mingming Niu#, Yingrui Wang#, Xuelian Cheng#, Biao Zhang#, Dong Zhang, Mengyao Liu, Rui Sun, Yezi Ma, Shihui Ma, Huijun Wang, Guoqing Zhu, Yang Lu, Baiming Huang, Pei Su, Xiaoyuan Chen, Jingjing Zhao, Hongtao Wang, Long Shen, Lixia Fu, Qianqian Huang, Yang Yang, He Wang, Chunlong Wu, Weigang Ge, Chen Chen, Qianyu Huo, Qingping Wang, Ying Wang, Li Geng, Yan Xie, Yi Xie, Lijun Liu, Jianwei Qi, Huaiyong Chen, Junping Wu, Erlie Jiang, Wentiao Jiang, Ximo Wang*, Zhongyang Shen*, Tiannan Guo*, Jiaxi Zhou*, Ping Zhu*, Tao Cheng*

Immunity. 2023 Jun 13;56(6):1410-1428.e8. doi.org/10.1016/j.immuni.2023.05.007. PMID: 37257450.

108

An immunometabolism subtyping system identifies S100A9+ macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis

Xuanwen Bao#*, Danyang Wang#, Xiaomeng Dai#, Chuan Liu#, Hangyu Zhang, Yuzhi Jin, Zhou Tong, Bin Li, Chuchu Tong, Shan Xin, Xin Li, Yanfang Wang, Lulu Liu, Xudong Zhu, Qihan Fu, Yi Zheng, Jingwen Deng, Weihong Tian, Tiannan Guo, Peng Zhao, Wenbin Chen*, and Weijia Fang*

Cell Reports Medicine. 2023 Apr 18;4(4):100987. doi: 10.1016/j.xcrm.2023.100987. PMID: 36990096.

104

Genome-wide genotype-serum proteome mapping provides insights into the cross ancestry differences in cardiometabolic disease susceptibility

Fengzhe Xu#, Evan Yi-Wen Yu#, Xue Cai#, Liang Yue#, Li-peng Jing#, Xinxiu Liang#, Yuanqing Fu, Zelei Miao, Min Yang, Menglei Shuai, Wanglong Gou, Congmei Xiao, Zhangzhi Xue, Yuting Xie, Sainan Li, Sha Lu, Meiqi Shi, Xuhong Wang, Wensheng Hu, Claudia Langenberg, Jian Yang, Yu-ming Chen*, Tiannan Guo* & Ju-Sheng Zheng*

Nature Communications. 2023 Feb 16;14(1):896. doi: 10.1038/s41467-023-36491-3. PMID: 36797296.

102

Proteomics Investigation of Diverse Serological Patterns in COVID-19

Xiao Liang#, Rui Sun, Jing Wang, Kai Zhou, Jun Li, Shiyong Chen, Mengge Lyu, Sainan Li, Zhangzhi Xue, Yingqiu Shi, Yuting Xie, Qiushi Zhang, Xiao Yi, Juan Pan, Donglian Wang, Jiaqin Xu, Hongguo Zhu, Guangjun Zhu, Jiansheng Zhu, Yi Zhu, Yufen Zheng*, Bo Shen*, and Tiannan Guo*

Molecular & Cellular Proteomics. 22(2): 100493. doi: 10.1016/j.mcpro.2023.100493. PMID: 36621767.

100

Longitudinal proteomic investigation of COVID-19 vaccination

Yingrui Wang#, Qianru Zhu#, Rui Sun#, Xiao Yi#, Lingling Huang, Yifan Hu, Weigang Ge, Huanhuan Gao, Xinfu Ye, Yu Song, Li Shao, Yantao Li, Jie Li*, Tiannan Guo*, Junping Shi*

Protein & Cell. 2023 Sep 14;14(9):668-682. doi: 10.1093/procel/pwad004. PMID: 36930526.