Dr. Tiannan Guo completed his clinical medicine training (1999–2006) at Tongji Medical College, Huazhong University of Science and Technology, and simultaneously pursued studies in biology (2001–2005) at Wuhan University. Subsequently, he earned a Ph.D. in cancer proteomics (2008–2012) in Singapore and conducted postdoctoral research at ETH Zurich (2012-2017). After a brief tenure as Scientific Director of ProCan, Children’s Medical Research Institute, The University of Sydney School in 2017, Dr. Guo relocated to Westlake University in August 2017 as a tenure-track Assistant Professor, achieving promotion to tenured Associate Professor in January 2023. He also directs the Westlake Center for Intelligent Proteomics at Westlake Laboratory.
Dr. Guo’s research group has pioneered the development of the PCT-DIA trace tissue proteomics technology, which significantly advances precision diagnosis and treatment research for major ailments such as infectious diseases and cancers, as well as aging. They developed the first mass spectrometry (MS)-based in vitro diagnostic (IVD) protein test for clinical applications. They have also developed AI-empowered expansion proteomics technologies that enable subcellular proteomics analysis of tissue sections using mass spectrometry. Additionally, the team has driven the development blueprint for artificial intelligence proteomics, establishing the AI-friendly, billion-level mass spectrometry corpus MassNet, and constructing a suite of mass spectrometry pre-training models, including DIA-BERT, DDA-BERT, and XuanjiNovo. Their contributions further encompass the proposal of a novel framework for artificial intelligence virtual cell construction and the establishment of ProteinTalks, the first virtual cell foundation model based on perturbation proteomics. More recently, they have proposed the ripple theory of drug development utilizing artificial intelligence and multi-omics, and launched the international consortium for AI Proteomics and Virtual Yeast.
Dr. Guo holds the presidency of the Chinese Proteomics Society, and serves as a Council Member of the Human Proteome Organization (HUPO). He is also an Associate Editor of Molecular & Cellular Proteomics, an Editorial Board Member of Genomics, Proteomics & Bioinformatics and Cell Systems, an Advisory Expert of Cell Reports Medicine, and a Scientific Advisor for Vita and Molecular Systems Biology.