Yingying obtained her PhD degree from Nanjing University, College of Life Science, and majored in Biology (2018-2021). During her doctoral study, she mainly focused on the mechanism of genomic hypermutation during sexual reproduction of Neurospora crassa using whole genome sequencing coupled with biochemical investigation. In July 2021, Yingying joined the Guomics team as a postdoctoral researcher for proteomic big data research. She and her colleagues developed a highly sensitive and accurate metaproteomic analysis workflow using 4D proteomics technology. This workflow was applied to study the functional expression profiles of gut microbiota in a large cohort, investigating the roles of specific gut microbial functions in metabolic diseases. In August 2023, She Joined Westlake Laboratory as assistant researcher. She and her colleagues conduct functional studies of gut microbiota, including bacteria and fungi using metaproteomics data. Additionally, they are developing a pre-trained model that leverages large language models and extensive metaproteomics data for deep metaproteome identification. She has also participated in metaproteomic research on tongue coating for gastric cancer screening.

Representative Publications

Long Wang, Yingying Sun, Xiaoguang Sun, Luyao Yu, Lan Xue, Zhen He, Ju Huang, Dacheng Tian, Laurence D. Hurst, Sihai Yang. Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life, Genome Biology, 2020, 1(21): 1-23 (Co-first author)

Jiahui Chen, Yingying Sun, Jie Li, Mengge Lyu, Li Yuan, Jiancheng Sun, Shangqi Chen, Can Hu, Qing Wei, Zhiyuan Xu, Tiannan Guo, Xiangdong Cheng. In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study, Microbiome, 2024, 12(1) (Co-first author)

Yingying Sun, Ziyuan Xing, Shuang Liang, Zelei Miao, Lai-bao Zhuo, Wenhao Jiang, Hui Zhao, Huanhuan Gao, Yuting Xie, Yan Zhou, Liang Yue, Xue Cai, Yu-ming Chen, Ju-Sheng Zheng, Tiannan Guo. metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis, bioRxiv, 2023 (First author)

Fangfei Zhang, Weigang Ge, Lingling Huang, Dan Li, Lijuan Liu, Zhen Dong, Luang Xu, Xuan Ding, Cheng Zhang, Yingying Sun, Jun A, Jinlong Gao, Tiannan Guo. A Comparative Analysis of Data Analysis Tools for Data-Independent Acquisition Mass Spectrometry, Molecular & Cellular Proteomics, 2023, 22(9): 100623

Haonan Duan, Zhibin Ning, Zhongzhi Sun, Tiannan Guo, Yingying Sun, Daniel Figeys. MetaDIA: A Novel Database Reduction Strategy for DIA Human Gut Metaproteomics, bioRxiv, 2024.

In preparation

Shuang Liang, Yingying Sun, Bang-yan Li, Zelei Miao, Bo Wang, Ziyuan Xing, Yuting Xie, Enci Cai, Sainan Li, Youqi Liu, Min Yang, Menglei Shuai, Wanglong Gou, Wenhao Jiang, Youming Wang, Huanhuan Gao, Ke Zhang, Jing Yu, Xue Cai, Xingbing Wang, Yu-ming Chen, Ju-Sheng Zheng, Tiannan Guo. Population-based metaproteomics reveals functional associations between gut microbiota and phenotypes.(Cell Under review) (202405) (Co-first author)

Patent

CN202210937044.1

Method and electronic device for metaproteomic analysis based on mass spectrometry data Inventors: Tiannan Guo, Yingying Sun, Shuang Liang, Ziyuan Xing, Wenhao Jiang.

Presentations

2023.05        Poster presentation for China Gut Conference 2023 (Beijing, China)

2023.09        Oral presentation for the HUPO 2023 (Busan, South Korea)

2023.09        Poster presentation for the CNHUPO 2023 (Chengdu, China)