Jun A, Ph.D. is a Research Assistant Professor at the Westlake Laboratory of Life Sciences and Biomedicine. He received his Ph.D. in Genetics from Nankai University in 2021. His early research focused on the discovery of prognostic biomarkers for prostate cancer through the integration of multi-omics data and machine learning methods. He developed diagnostic and recurrence risk prediction models for castration-resistant prostate cancer (CRPC) and investigated the functional role of MCM4 in relation to androgen signaling. In 2021, he joined the Guomics team as a postdoctoral fellow, where he expanded his research into proteomics big data and artificial intelligence–driven data analysis. Since 2023, his work has focused on the development of deep learning methods for mass spectrometry data analysis, with an emphasis on computational approaches for large-scale proteomics.
Representative Publications
[Note: *, co-corresponding; #, co-first author]
1. A Jun#, Xiang Zhang#, Xiaofan Zhang#, Jiaqi Wei#, Te Zhang, Yamin Deng, Pu Liu, Zongxiang Nie, Yi Chen, Nanqing Dong, Zhiqiang Gao*, Siqi Sun*, Tiannan Guo*. MassNet: billion-scale AI-friendly mass spectral corpus enables robust de novo peptide sequencing. Nature Methods. Under minor revision.
2. A Jun#, Pu Liu#, Yingying Sun#, Jiaying Lin, Xiaofan Zhang, Zongxiang Nie, Yuqi Zhang, Ziyuan Xing, Yi Chen*, Tiannan Guo*. DDA-BERT: leveraging transformer architecture pre-training for data-dependent acquisition mass spectrometry-based proteomics. Nature Communications. In principle accepted.
3. Yingying Sun, Jun A, Zhiwei Liu, Rui Sun, Liujia Qian, Samuel H. Payne, Wout Bittremieux, Markus Ralser, Chen Li, Yi Chen, Zhen Dong, Yasset Perez-Riverol, Asif Khan, Chris Sander, Ruedi Aebersold, Juan Antonio Vizcaíno, Jonathan R Krieger, Jianhua Yao, Han Wen, Linfeng Zhang, Yunping Zhu, Yue Xuan, Benjamin Boyang Sun, Liang Qiao, Henning Hermjakob, Haixu Tang, Huanhuan Gao, Yamin Deng, Qing Zhong, Cheng Chang, Nuno Bandeira, Ming Li, Weinan E, Siqi Sun, Yuedong Yang, Gilbert S. Omenn, Yue Zhang, Ping Xu, Yan Fu, Xiaowen Liu, Christopher M. Overall, Yu Wang, Eric W. Deutsch, Luonan Chen, Jürgen Cox, Vadim Demichev, Fuchu He, Jiaxing Huang, Huilin Jin, Chao Liu, Nan Li, Zhongzhi Luan, Jiangning Song, Kaicheng Yu, Wanggen Wan, Tai Wang, Kang Zhang, Le Zhang, Peter A. Bell, Matthias Mann*, Bing Zhang*, Tiannan Guo*. Strategic priorities for transformative progress in advancing biology with proteomics and artificial intelligence. Nature Methods. In principle accepted.
4. Rui Sun#, Jun A#, Haolan Yu#, Yan Wang#, Miaoxia He#, Lingling Tan, Jili Zhang, Yingrui Wang, Xiaochen Sun, Mengge Lyu, Min Qu, Lingling Huang, Zhenyang Dong, Weigang Ge, Yun Zhang, Honghan Cheng, Xuan Ding, Bo Yang, Jianguo Hou, Chuanliang Xu, Linhui Wang, Yi Zhu, Tiannan Guo*, Xu Gao*, Chenghua Yang*. Proteomic landscape profiling of primary prostate cancer reveals a 16-ptotein panel for prognosis prediction. Cell Reports Medicine. 2024;5(8):101679. doi: 10.1016/j.xcrm.2024.101679.
5. Zhangzhi Xue, Tiansheng Zhu, Fangfei Zhang, Cheng Zhang, Nan Xiang, Liujia Qian, Xiao Yi, Yaoting Sun, Wei Liu, Xue Cai, Linyan Wang, Xizhe Dai, Liang Yue, Lu Li, Thang V Pham, Sander R Piersma, Qi Xiao, Meng Luo, Cong Lu, Jiang Zhu, Yongfu Zhao, Guangzhi Wang, Junhong Xiao, Tong Liu, Zhiyu Liu, Yi He, Qijun Wu, Tingting Gong, Jianqin Zhu, Zhiguo Zheng, Juan Ye, Yan Li, Connie R Jimenez*, Jun A*, Tiannan Guo*. DPHL v.2: An updated and comprehensive DIA pan-human assay library for quantifying more than 14,000 proteins. Patterns. 2023;4(7):100792. doi:10.1016/j.patter.2023.100792.
6. Jun A, Baotong Zhang, Zhiqian Zhang, Hailiang Hu, Jin-Tang Dong*. Novel gene signatures predictive of patient recurrence-free survival and castration resistance in prostate cancer. Cancers, 2021, 13(4):917. doi:10.3390/cancers13040917.
7. Jaco C Knol, Mengge Lyu, Franziska Böttger, Madalena Nunes Monteiro, Thang V Pham, Frank Rolfs, Andrea Vallés-Martí, Tim Schelfhorst, Richard R de Goeij-de Haas, Irene V Bijnsdorp, Shuaiyao Wang, Fangfei Zhang, Jun A, Bart A Westerman , Barbara Sitek, Janne Lehtiö, Jan Koster, Jan N M IJzermans, Hanneke W M van Laarhoven, Maarten F Bijlsma1, Jan Paul Medema1, Alex A Henneman, Sander R Piersma, Ruud H Brakenhoff, Jacqueline Cloos, Valentina Cordo’, Daphne de Jong, Geert Kazemier, Danijela Koppers-Lalic, Mariette Labots, Tessa Y S Le Large, John W M Martens, Jules P P Meijerink, Madiha Mumtaz, Chantal Scheepbouwer1, Robby E Kibbelaar, David P Noske, Renske D M Steenbergen, Nicole C T van Grieken, Winan van Houdt, Elisa Giovannetti, Geert J L H van Leenders, Jos Jonkers, Tong Liu, Meisi Yan, Xiaolu Zhan, Tiannan Guo*, Connie R Jimenez*. The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets. Cancer Cell. 2025;43(7):1328-1346.e8. doi: 10.1016/j.ccell.2025.05.003.
8. Mingcheng Liu, Qingqing Huang, Jun A, Linyue Li, Xiawei Li, Zhiqian Zhang, Jin-Tang Dong*. The Cardiac Glycoside Deslanoside Exerts Anticancer Activity in Prostate Cancer Cells by Modulating Multiple Signaling Pathways. Cancers. 2021;13(22):5809. doi: 10.3390/cancers13225809.
9. Changying Fu, Na An, Jinming Liu, Jun A, Baotong Zhang, Mingcheng Liu, Zhiqian Zhang, Liya Fu, Xinxin Tian, Dan Wang, Jin-Tang Dong*. The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxiainducible factor 1alpha in liver cancer cells. J Biol Chem. 2020;295(20):7060-7074. doi: 10.1074/jbc.RA119.012131.
10. Rui Wu, Jiali Fang, Mingcheng Liu, Jun A, Jinming Liu, Wenxuan Chen, Juan Li, Gui Ma, Zhiqian Zhang, Baotong Zhang, Liya Fu, Jin-Tang Dong*. SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation. J Biol Chem. 2020;295(19):6741-6753. doi: 10.1074/jbc.RA119.012338.
11. Xing Fu, Zhiqian Zhang, Rui Chen, Jun A, Na An, Xinxin Tian, Jin-Tang Dong*. ZFHX3 is integral to androgen/AR signaling involving protein association with AR in prostate cancer cells. Scientific reports. 2025;15(1):20931. doi: 10.1038/s41598-025-05659-w.
12. Qingxia Hu, Baotong Zhang, Rui Chen, Changying Fu, Jun A, Xing Fu, Juan Li, Liya Fu, Zhiqian Zhang, Jin-Tang Dong*. ZFHX3 is indispensable for Erβ to inhibit cell proliferation via MYC downregulation in prostate cancer cells. Oncogenesis. 2019;8(4):28. doi: 10.1038/s41389-019-0138-y.
13. Xiawei Li, Zhiqian Zhang, Mingcheng Liu, Xing Fu, Jun A, Guoan Chen, Shian Wu, Jin-Tang Dong*. Establishment of a lncRNA-Based Prognostic Gene Signature Associated With Altered Immune Responses in HCC. Frontiers in immunology. 2022;13:880288. doi: 10.3389/fimmu.2022.880288.
14. Xing Fu, Zhiqian Zhang, Mingcheng Liu, Juan Li, Jun A, Liya Fu, Chenyang Huang, Jin-Tang Dong*. AR imposes different effects on ZFHX3 transcription depending on androgen status in prostate cancer cells. Journal of cellular and molecular medicine. 2022;26(3):800-812. doi: 10.1111/jcmm.17125.
15. Juan Li, Baotong Zhang, Mingcheng Liu, Xing Fu, Xinpei Ci, Jun A, Changying Fu, Ge Dong, Rui Wu, Zhiqian Zhang, Liya Fu, Jin-Tang Dong*. KLF5 Is crucial for androgen-AR signaling to transactivate genes and promote cell proliferation in prostate cancer cells. Cancers. 2020;12(3):748. doi: 10.3390/cancers12030748.
16. Ge Dong, Gui Ma, Rui Wu, Jinming Liu, Mingcheng Liu, Ang Gao, Xiawei Li, Jun A, Xiaoyu Liu, Zhiqian Zhang, Baotong Zhang, Liya Fu, Jin-Tang Dong*. ZFHX3 promotes the proliferation and tumor growth of ER-positive breast cancer cells likely by enhancing stem-like features and MYC and TBX3 transcription. Cancers. 2020;12(11):3415. doi: 10.3390/cancers12113415.
17. Qiao Wu, Changying Fu, Menglin Li, Juan Li, Zhigui Li, Leilei Qi, Xinpei Ci, Gui Ma, Ang Gao, Xing Fu, Jun A, Na An, Mingcheng Liu, Yixiang Li, Jamie L King, Liya Fu, Baotong Zhang, Jin-Tang Dong*. CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth. Int J Cancer. 2019;144(3):582-594. doi: 10.1002/ijc.31908.
18. Fangfei Zhang, Weigang Ge, Lingling Huang, Dan Li, Lijuan Liu, Zhen Dong, Luang Xu, Xuan Ding, Cheng Zhang, Yingying Sun, Jun A, Jinlong Gao, Tiannan Guo*. A Comparative Analysis of Data Analysis Tools for Data-Independent Acquisition Mass Spectrometry. Mol Cell Proteomics. 2023;22(9):100623. doi: 10.1016/j.mcpro.2023.100623.
Patents
已授权专利：
高旭; 郭天南; 阿俊; 杨成华; 孙瑞; 于浩澜; 薛芊; 瞿旻; 一类新型前列腺癌治疗靶点及其在前列腺癌治疗中的应用:202311031168.4[P].2025-12-02. (专利，已授权)
申请中专利：
郭天南; 杨成华; 高旭; 阿俊; 孙瑞; 王燕; 前列腺癌预后预测模型构建方法、装置及存储介质:202310723222.5[P].2023-09-12. (专利，已递交)。