王瑛睿于清华大学生命科学学院生物学专业直博（2013-2019），主要研究MAPK相关激酶LF4对纤毛长度调控的机制，采用蛋白组学以及磷酸化蛋白质组学比较分析，进一步探究LF4的互作蛋白。2019年7月至2020年12月，在浙江清华长三角研究院工作。2021年1月，加入Guomics团队成为博士后，主要针对前列腺癌，以及新冠疫苗展开蛋白质组学研究。

Representative Publications

Yingrui Wang^#, Qianru Zhu^#, Rui Sun^#, Xiao Yi^#, Lingling Huang, Yifan Hu, Weigang Ge, Huanhuan Gao, Xinfu Ye, Yu Song, Li Shao,Yantao Li, Jie Li*, Tiannan Guo*, Junping Shi*. Longitudinal proteomic investigation of COVID-19 vaccination. Protein&Cell, 2023, 14(9): 668-682.

Hong Wang*^,#, Cuicui Liu^#, Xiaowei Xie^#, Mingming Niu^#, Yingrui Wang^#, Xueliang Cheng^#, Biao Zhang^#, Dong Zhang, Mengyao Liu, Rui Sun, Yezi Ma, Shihui Ma , Huijun Wang, Guoqing Zhu, Yang Lu,Baiming Huang, Pei Su, Xiaoyuan Chen, Jingjing Zhao, Hongtao Wang, Long Shen, Lixia Fu, Qianqian Huang, Yang Yang, He Wang, Chunlong Wu, Weigang Ge, Chen Chen, Qianyu Huo, Qingping Wang, Ying Wang, Li Geng, Yan Xie, Yi Xie, Lijun Liu, Jianwei Qi, Huaiyong Chen, Junping Wu, Erlie Jiang, Wentao Jiang, Ximo Wang^∗, Zhongyang Shen^∗, Tiannan Guo^∗, Jiaxi Zhou^∗, Ping Zhu^∗, Tao Cheng^∗. Immunity, 2023, 56(6): 1410-1428.

Yingrui Wang^#, Yahui Ren, Junmin Pan. Regulation of flagellar assembly and length in Chlamydomonas by LF4, a MAPK-related kinase. The FASEB Journal. 2019, 33(5): 6431-6441.

Tian Lu^#, Yingrui Wang, Tiannan Guo. Multi-omics in COVID-19: Seeing the unseen but overlooked in the clinic. Cell Reports Medicine. 2022. DOI: 10.1016/j.xcrm.2022.100580.

Xiao Liang*, Yingrui Wang, Tiannan Guo. Proteomics approaches to long COVID: status and outlooks. Life Medicine, 2023, 2(3): 1-3.

Rui Sun^#, Jun A^#, Haolan Yu^#, Yan Wang^#, Miaoxia He^#, Lingling Tan, Honghan Cheng, Jili Zhang, Yingrui Wang, Xiaochen Sun, Mengge Lyu, Min Qu, Lingling Huang, Zijian Li, Wenhui Zhang, Kunpeng Ma, Zhenyang Dong, Weigang Ge, Yun Zhang, Xuan Ding, Bo Yang, Jianguo Hou, Chuanliang Xu, Linhui Wang, Yi Zhu, Tiannan Guo*, Xu Gao*, Chenghua Yang*. Cell Reports Medicine. 2024. Proteomic landscape profiling of primary prostate cancer reveals a 16-ptotein panel for prognosis prediction (Accepted).

Rui Sun^#, Mengge Lyu, Shuang Liang, Weigang Ge, Yingrui Wang, Xuan Ding, Cheng Zhang, Yan Zhou, Shanjun Chen, Lirong Chen, Tiannan Guo. A prostate cancer tissue specific spectral library for targeted proteomic analysis. Proteomics. 2021. DOI: 10.1002/pmic.202100147.

In preparation

Xi Zheng^#, Yingrui Wang^#, He Wang^#, Wanmao Ni, Wei Dai, Yaoting Sun, Jiatong Wang, Shu Zheng, Kefeng Ding, Yeting Hu*, Tiannan Guo*, Ting Chen*. A Plasma Protein Classifier to Predict Colorectal Cancer and its Liver Metastasis. 2024 (Submitted).

Yan Zhou^#, Yingrui Wang^#, Xiao Shi^#, Jiatong Wang^#, Zelin Zang^#, Likun Zhang^#, Zhiqiang Gui, et al, Yaoting Sun*, Zhiyan Liu*, Yu Wang*, Tiannan Guo *. Proteogenomic profiling of medullary thyroid cancer for prognosis prediction. 2024 (in preparation).

Patents

已授权专利：

郭天南; 梁潇; 石颖秋; 王瑛睿 ; 一种高效清除液相色谱中多肽残留的方法及应用, 2022-11-11, 中国, ZL202210103388.2 (专利，已授权)。

程涛; 王洪; 王瑛睿; 郭天南; 牛明明; 周家喜; 王西墨; 蒋文涛; 王赫; 祁健伟; 刘利军; 武俊平; 谢炎; 马士卉 ; 测定样本中生物标志物水平的试剂在预测奥密克戎复阳风险的应用及代谢、蛋白、联合模型, 2022-11-25, 中国, ZL202211016042.5 (专利，已授权)。

丁克峰; 郭天南; 陈婷; 郑希; 王赫; 王瑛睿; 胡烨婷; 蛋白标志物组合在制备结直肠癌早期诊断产品中的应用, 2024-03-14, 中国, ZL202410294264.6 (专利，刚授权)

郭天南; 施军平; 王瑛睿; 朱倩茹; 胡一凡; 邵丽 ; 预测COVID-19疫苗接种后不同免疫应答人群的蛋白标志物及应用, 2022-3-25, 中国, ZL202210299567.8 (专利，刚授权)。

申请中专利：

郭天南; 丁克峰; 王瑛睿 ; 陈婷; 郑希; 王赫; 胡烨婷 ; 预测结直肠癌肝转移的生物标志物组合、试剂盒、系统及其应用, 2024-05-17, 中国, CN202410618368.8 (专利，已递交)。

Grants

Yingrui Wang, National Natural Science Foundation of China (Young Scientist Fund)：Proteomic big data and machine learning empowered research on host immune responses before and after COVID-19 vaccination (Grant No. 32200763) 2023.01-2025.12. 王瑛睿，国家自然科学基金（青年科学基金项目）：基于蛋白质组大数据和机器学习的新冠疫苗接种前后的宿主免疫反应系统研究（项目批准号：32200763）2023.01-2025.12（主持，在研）。

”Pioneer” and “Leading Goose” R&D Program of Zhejiang: AI empowered multi-omics for early screening and diagnosis of lung cancer (Grant No. 2023C03056) 2023.01-2025.12 (Participate) 浙江省“尖兵”“领雁”研发攻关计划资助项目：AI赋能多组学跨膜态的肺癌早期筛查诊断技术研究（编号：2023C03056）2023.01-2025.12（参与，在研）。

The Key Research and Development Program of Zhejiang Province (Grant No. 2022C03037) 2022.01-2023.12. 浙江省“尖兵”“领雁”研发攻关计划项目：流式质谱细胞分析技术（编号：2022C03037）2022.01-2023.12（参与，结题）。