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Xue received her training in analytical chemistry from Zhejiang University of Technology (2011-2018), specializing in chromatography and mass spectrometry. She joined the Guomics lab as a research assistant in April 2018 and was awarded for outstanding performance at Westlake University in 2019. Pursuing her academic career, Xue began her PhD in the Guomics lab in August 2021, completed her doctorate in June 2025, and immediately transitioned to a postdoctoral position in July 2025. Her research focuses on developing and optimizing proteomics methods, clinical proteomics research, and translational medicine, bridging cutting-edge techniques with practical clinical applications.

Representative Publications:

[Note: #, co-first author; *co-corresponding]

1. Xue Cai#, Zhangzhi Xue#, et al., Tiannan Guo*. Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome. Cell Rep Med, 2023. 4(9): p. 101172.
2. Xue Cai, Zhangzhi Xue, et al., Tiannan Guo*. High-throughput proteomic sample preparation using pressure cycling technology. Nature Protocols, 2022. 17(10): p. 2307-2325.
3. Xue Cai#, Weigang Ge#, et al., Yi Zhu*, Tiannan Guo*. PulseDIA: Data-Independent Acquisition Mass Spectrometry Using Multi-Injection Pulsed Gas-Phase Fractionation. J Proteome Res, 2021. 20(1): p. 279-288.
4. Qing-Qing Tao#, Xue Cai#, et al., Tiannan Guo*, Zhi-Ying Wu*. Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling. The Innovation, 2024. 5(1): p. 100544.
5. Ying Zhang#, Xue Cai#, et al., Yi Zhu*, Tiannan Guo*. Potential Use of Serum Proteomics for Monitoring COVID-19 Progression to Complement RT-PCR Detection. J Proteome Res, 2022. 21(1): p. 90-100.
6. Jinjian Xu#, Xue Cai#, et al., Tiannan Guo*, Yu-ming Chen*. Proteome-wide profiling reveals dysregulated molecular features and accelerated aging in osteoporosis: A 9.8-year prospective study. Aging Cell, 2023: p. e14035.
7. Fengzhe Xu#, Evan Yi-Wen Yu#, Xue Cai#, et al., Tiannan Guo*, Ju-Sheng Zheng*. Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility. Nat Commun, 2023. 14(1): p. 896.
8. Wanglong Gou#, Yuanqing Fu#, Liang Yue#, Geng-Dong Chen#, Xue Cai#, et al., Tiannan Guo*, Ju-Sheng Zheng*. Gut microbiota, inflammation, and molecular signatures of host response to infection. J Genet Genomics, 2021. 48(9): p. 792-802.

Oral talks/posters

2023.09, Human Proteome Organization (HUPO) conference; Busan, South Korea; Poster: Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome.

2023.09, CNHUPO; Chengdu, China; Oral presentation: Preoperative diagnosis of thyroid nodules using a novel multi-omics classifier test.

2023.09, China Proteomics Conference; Chengdu, China; Excellent poster: Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome.

2019.12, 9th Zhejiang Analysis and Testing Association Academic Conference; Oral presentation: PulseDIA: in-depth data independent acquisition mass spectrometry using enhanced gas phase fractionation.

Patents:

1. 脉冲式数据非依赖性采集质谱检测蛋白质组学的方法；郭天南，朱怡，蔡雪，葛伟刚
2. 预测未来时间段内患代谢综合征概率的蛋白标志物及应用；郭天南，郑钜圣，陈裕明，蔡雪，王博。
3. 一种融合靶向和非靶向的蛋白质组学方法；郭天南，蔡雪，葛伟刚。

Academic Awards

2021-2022 academic year, Suwu Scholarship

2022-2023 academic year, Yiqiao First-class Scholarship

2021-2022, 2022-2023 academic year, Zhejiang University Outstanding Graduate, Zhejiang University Excellent Graduate

2020.01, Westlake University 2019 Advanced Worker

2019.12, Third Prize for Excellent Paper at the 9th Zhejiang Province Analytical Testing Academic Conference

2017-2018: Zhejiang University of Technology Outstanding Graduate at the university level (Ranking 1/15 in comprehensive performance)

2016-2017: Zhejiang University of Technology First-class Academic Scholarship at the university level (Ranking 34/179 in comprehensive performance), Social Work Award, Outstanding Graduate Cadre

2015-2016: Zhejiang University of Technology “Xin’an Chemical” Enterprise Scholarship (Ranking 17/195 in comprehensive performance), First-class Academic Scholarship at the university level, Outstanding League Cadre

2013-2014: Zhejiang University of Technology Social Work Award, Outstanding League Cadre